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KMID : 0931320210210030226
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대한상부위장관.헬리코박터학회지
2021 Volume.21 No. 3 p.226 ~ p.234
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Five Autoimmune Gastritis Patients with Positive Findings of Serum Anti-parietal Cell Antibodies
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Jeong Jong-Hyeon
Lee Sun-Young
Han Hye-Seung
Kim Jeong-Hwan
Sung In-Kyung
Park Hyung-Seok
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Abstract
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Autoimmune gastritis is a corpus-dominant type of gastritis with positive serum anti-parietal cell antibodies (APCA) and/or anti-intrinsic factor antibodies. Serum APCA and pepsinogen (PG) assays were performed in subjects with corpus-dominant gastritis detected by endoscopy. Serum APCA was positive in five patients. All these patients were postmenopausal women (four Koreans and one Caucasian from the Russian Federation) with a mean age of 59.0±3.2 years. They displayed low PG I levels ranging from 8.1 to 18.8 ng/mL (mean, 11.4±4.8 ng/mL) and low PG I/II ratios ranging from 0.7 to 2.4 (mean, 1.2±0.7). Three of the patients were being treated for autoimmune thyroiditis. Multiple gastric neuroendocrine tumors were observed in two Helicobacter pylori (H. pylori)-naive patients with high serum gastrin levels exceeding 700 pg/mL and serum chromogranin A levels exceeding 1,000 ng/mL. In the remaining three patients, intestinal metaplasia was observed in the biopsied specimens from the antrum, suggesting a history of H. pylori infection. Our findings indicate the value of positive serum APCA findings, low serum PG I levels, and low serum PG I/II ratios in confirming autoimmune gastritis in patients showing corpus-dominant atrophy, regardless of their H. pylori infection status.
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KEYWORD
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Atrophic gastritis, Autoimmune diseases, Neuroendocrine tumors, Parietal cells
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